EPA’s IRIS program has made substantial progress, says new report

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EPA’s IRIS program has made substantial progress, says new report

WASHINGTON – The U.S. Environmental Protection Agency’s (EPA) Integrated Risk Information System (IRIS) program has made “substantial progress” in implementing recommendations outlined in past reports by the National Academies of Sciences, Engineering, and Medicine, improving the program’s overall scientific and technical performance, says a new Academies report. The program, which is used to assess the hazards posed by environmental contaminants, remains a work in progress and should continue to evolve as it adapts and applies new scientific practices and knowledge, the report says.

The transformation of the IRIS process began several years ago after the release of a 2011 Academies report that provided suggestions for creating a more systematic and transparent IRIS process. In a 2014 report, the Academies reviewed the changes implemented in the program since 2011 and concluded that the improvements were considerable. Under the program’s new leadership, EPA asked the National Academies to review again the agency’s progress toward addressing past recommendations.

The Academies’ latest review finds that IRIS has made substantial progress in incorporating systematic-review methods into its process and assessments. IRIS has also established a systematic-review working group and engaged subject-matter experts. According to the new report, these groups should increase efficiency and consistency among assessments and improve the scientific rigor of the assessments.

“The changes in the IRIS program over such a short period of time are impressive,” said Jonathan Samet, dean of the Colorado School of Public Health and chair of the committee that wrote the report. “We see a substantial commitment at EPA to use systematic-review methods in conducting assessments, which are important for identifying, evaluating, and summarizing the findings from current literature and integrating the evidence available to inform decisions.”

The committee also said the program has developed a number of collaborations with such groups as the World Health Organization, the National Toxicology Program Office of Health Assessment and Translation, and the European Food Safety Authority that will help position the IRIS program as a leader in advancing systematic-review methods.

The report offers recommendations for some refinements and further development in different stages of its systematic-review process and risk quantification process and urges EPA to give high priority to completion, peer review, and release of its IRIS handbook, which is expected to provide critical guidance for the development of IRIS assessments. The committee noted, however, that EPA is describing its approach in IRIS protocols, and this practice provides transparency while the handbook is being completed.

The study was sponsored by EPA. The National Academies of Sciences, Engineering, and Medicine are private, nonprofit institutions that provide independent, objective analysis and advice to the nation to solve complex problems and inform public policy decisions related to science, technology, and medicine. The National Academies operate under an 1863 congressional charter to the National Academy of Sciences, signed by President Lincoln. For more information, visit http://national-academies.org.

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Copies of Progress Toward Transforming the Integrated Risk Information System (IRIS) Program: A 2018 Evaluation are available at http://www.nap.edu or by calling 202-334-3313 or 1-800-624-6242. Reporters may obtain a copy from the Office of News and Public Information (contacts listed above).

THE NATIONAL ACADEMIES OF SCIENCES, ENGINEERING, AND MEDICINE

Division on Earth and Life Studies
Board on Environmental Studies and Toxicology

Committee to Review Advances Made to the IRIS Process

Jonathan M. Samet* (chair)

Dean

Colorado School of Public Health

Colorado State University

Aurora

Richard A. Corley

Laboratory Fellow (retired)

Pacific Northwest National Laboratory

Boise, Idaho

George Daston

Victor Mills Society Research Fellow

Procter & Gamble Co.

Mason, Ohio

David C. Dorman

Professor of Toxicology

Department of Molecular Biomedical Sciences

North Carolina State University

Raleigh

Russ B. Hauser

Chair

Department of Environmental Health, and

Frederick Lee Hisaw Professor of Reproductive Physiology

Harvard T.H. Chan School of Public Health

Boston

Karen A. Robinson

Associate Professor of Medicine, and

Director, JHU Evidence-Based Practice Center

School of Medicine

Johns Hopkins University

Baltimore

Richard P. Scheines

Professor of Philosophy and Dean

Dietrich College of Humanities and Social Sciences

Carnegie Mellon University

Pittsburgh

Lauren Zeise

Director

Office of Environmental Health Hazard Assessment

California Environmental Protection Agency

Oakland

Yiliang Zhu

Professor

Division of Epidemiology, Biostatistics, and Preventive Medicine

School of Medicine

University of New Mexico

Albuquerque

STAFF

Ellen K. Mantus

Study Director

* Member, National Academy of Medicine

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